There are two main routes to the Sanctuary from Brownsville, Texas.
Option 1 – International to Southmost
From US 77/83 in Brownsville: Exit onto International Boulevard go East. After 3/4 mile, turn right onto Southmost Road (FM 1419). Continue on Southmost Road (FM 1419) for 6 miles; look for entrance sign on the right.
Option 2 – Boca Chica to FM511
From US 77/83 and Boca Chica (Hwy 4). Go East on Boca Chica past airport to FM 511. Turn right on FM 511. Follow 511 straight through to the four way stop. Continue straight on FM 3068 to Southmost (FM 1419). Turn right, go half a mile and the entrance is on your left.